Table 2.
Wheal inhibition (%) after drug intakea
| Time point after dose | LCTZb | FEXb | PLCb | LCTZ-FEXc | LCTZ-PLCc | FEX-PLCc |
|---|---|---|---|---|---|---|
| 2 h | 65.8(54.6, 77.1) | 64.7(53.5, 75.9) | 17.9(6.5, 29.3) | 1.14(−14.2, 16.5)(P= 0.882) | 48.0(32.5, 63.4)(P< 0.001) | 46.8(31.3, 62.3)(P< 0.001) |
| 24 h | 72.8(62.0, 83.6) | 23.0(12.2, 33.8) | 2.4(−8.6, 13.4) | 49.8(34.8, 64.9)(P< 0.001) | 70.4(55.3, 85.6)(P< 0.001) | 20.6(5.4, 35.8)(P= 0.009) |
a
Wheal inhibition is defined as the reduction of wheal area measured before and after drug intake expressed in (%).
b
Values given are LS mean (95% CI).
c
Values given are change in LS mean (95% CI). CI, confidence interval; LCTZ, levocetirizine; FEX, fexofenadine; PLC, placebo.