Table 3.
Urinary desalkylebastine and carebastine values (µmol) (mean ± SD (95% CI)) according to CYP2J2*7, CYP3A4*1B, CYP3A5*3 and MDR1C3435T genotypes
| Genotype | n | Desalkylebastine | Carebastine |
|---|---|---|---|
| CYP2J2*7 | |||
| *1/*1 | 77 | 19.7 ± 17.6 (15.7, 23.7) | 24.6 ± 16.0 (20.1, 28.2) |
| *1/*7 | 12 | 21.2 ± 21.9 (7.3, 35,2) | 22.9 ± 16.2 (12.6,33.2) |
| CYP3A4*1B | |||
| *1 A/*1 A | 82 | 20.0 ± 18.2 (16.0, 24.0) | 24.7 ± 16.5 (21.0, 28.3) |
| *1 A/*1B | 7 | 18.7 ± 17.5 (2.5, 34.8) | 21.2 ± 7.1 (14.6, 27.8) |
| CYP3A5*3 | |||
| *1/*1 +*1/*3 | 16 | 23.6 ± 24.3 (10.6, 36.6) | 23.4 ± 11.0 (17.6, 29.3) |
| *3/*3 | 73 | 19.1 ± 16.5 (15.2, 22.9) | 24.6 ± 16.9 (20.7, 28.6) |
| MDR1C3435T | |||
| CC | 18 | 17.5 ± 12.4 (11.3, 23.6) | 32.3 ± 18.3* (23.2, 41.4) |
| CT | 49 | 21.7 ± 21.4 (15.6, 27.8) | 22.8 ± 14.7 (18.6, 27.0) |
| TT | 22 | 17.9 ± 13.7 (11.8, 23.9) | 21.5 ± 15.3 (14.7, 28.3) |
n, number of individuals;
*
P < 0.05 vs. the other C3435T genotypes.