Table 1.

Demographic data for study subjects

Variable	Male	Female
N	10	10
Age (years)	34.8 ± 7.9	38.2 ± 9.3
Total body weight (kg)	76.3 ± 13.3	79.5 ± 20.1
Ideal body weight (kg)	74.0 ± 6.8 kg	58.5 ± 6.3*
Midazolam dose (mg)	1.9 ± 0.3	2.0 ± 0.5
Aspartate aminotransferase (U l−1)	24.2 ± 4.8	24.0 ± 7.4
Alanine aminotransferase (U l−1)	30.1 ± 8.3	24.6 ± 9.2
Creatinine clearance (ml min−1 1–1.73 m2)†	99.4 ± 14.7	81.3 ± 19.7*
Length of menstrual cycle (days)		27.2 ± 2.3
Follicular phase study day		5.6 ± 1.4
Luteal phase study day		18.3 ± 3.3

Data are given as mean±SD.

^*P < 0.05 compared with men.

^†Creatinine clearance was calculated using the Cockcroft and Gault method.