Figure 1.

Pharmacokinetic and pharmacodynamic model of the interaction between SJW and CsA. X is the daily intake of SJW (mg day⁻¹), K_s is the rate constant of synthesis of detoxicating proteins (AU/month), k_e is the elimination rate constant of the detoxicating proteins (/month), P is the amount of the detoxicating proteins (AU), D is the daily dose of CsA (mg day⁻¹), C is CsA trough blood concentration (ng ml⁻¹), K_s0 is the rate constant of detoxicating proteins in the absence of SJW (AU/month), I_max is the maximal induction potency of SJW for detoxicating proteins, K_m is the dose of SJW required to induce half-maximal induction (mg day⁻¹), and α is a constant ((ng ml⁻¹)/(mg day⁻¹)/AU)