Table 2.
The polymorphisms studied and their association with torsemide renal clearance
| No. | Identification* | MAF† | Nucleotides | N | ClTor (ml min−1)‡ | P-value§ |
|---|---|---|---|---|---|---|
| Polymorphisms at SLC22A6 and SLC22A8 | ||||||
| 1 | rs736342 | 0.12 | C/C | 75 | 15.3 (14.7–15.9) | |
| C/T | 17 | 17.3 (15.7–19.1) | ||||
| T/T | 3 | 14.7 (13.5–15.9) | ||||
| 2 | rs10897312 | 0.12 | C/C | 76 | 15.3 (14.7–15.9) | |
| C/T | 16 | 16.5 (15.1–17.9) | ||||
| T/T | 3 | 21.9 (18.6–25.9) | ||||
| 3 | rs955434 | 0.29 | G/G | 48 | 15.3 (14.6–16.2) | |
| G/A | 37 | 15.6 (14.8–16.5) | ||||
| A/A | 9 | 17.5 (15.5–19.7) | ||||
| 4 | rs953894 | 0.25 | G/G | 53 | 15.3 (14.5–16.0) | |
| G/A | 36 | 16.0 (15.1–17.0) | ||||
| A/A | 6 | 16.8 (14.9–18.9) | ||||
| 5 | rs2276299 | 0.13 | T/T | 70 | 15.6 (15.0–16.3) | |
| T/A | 23 | 16.0 (14.9–17.1) | ||||
| A/A | 1 | 8.8 | ||||
| 6 | rs2187383 | 0.36 | G/G | 36 | 16.3 (15.5–17.2) | |
| G/T | 49 | 15.4 (14.6–16.2) | ||||
| T/T | 10 | 14.5 (13.1–16.0) | ||||
| 7 | rs4963326 | 0.31 | C/C | 46 | 14.8 (14.1–15.5) | |
| C/T | 40 | 16.4 (15.6–17.3) | ||||
| T/T | 9 | 16.9 (14.4–19.9) | ||||
| 8 | rs948979 | 0.23 | G/G | 57 | 14.9 (14.3–15.6) | |
| G/T | 32 | 17.8 (16.8–19.0) | ||||
| T/T | 6 | 12.0 (10.7–13.5) | ||||
| 9 | rs10792369 | 0.29 | T/T | 49 | 14.7 (14.0–15.5) | |
| T/C | 35 | 17.2 (16.3–18.1) | ||||
| C/C | 10 | 15.0 (12.9–17.4) | ||||
| Polymorphisms at SLC22A11 | ||||||
| 10 | rs11231809 | 0.43 | A/A | 30 | 18.0 (16.7–19.5) | 0.002 |
| A/T | 49 | 15.1 (14.5–15.8) | ||||
| T/T | 16 | 13.3 (12.7–13.9) | ||||
| 11 | rs4930423 | 0.44 | A/A | 28 | 13.6 (13.0–14.2) | 0.034 |
| A/C | 48 | 16.8 (16.1–17.6) | ||||
| C/C | 17 | 16.4 (14.7–18.4) | ||||
| 12 | rs3759053 | 0.45 | T/T | 27 | 16.9 (15.7–18.3) | 0.009 |
| T/C | 49 | 16.2 (15.5–16.9) | ||||
| C/C | 18 | 12.7 (11.9–13.4) | ||||
| 13 | rs3782099 | 0.47 | C/C | 25 | 17.0 (15.7–18.4) | 0.009 |
| C/T | 51 | 16.2 (15.5–17.0) | ||||
| T/T | 19 | 12.8 (12.1–13.5) | ||||
| 14 | rs1783811 | 0.31 | G/G | 46 | 17.4 (16.5–18.4) | 0.007 |
| G/A | 40 | 14.1 (13.4–14.8) | ||||
| A/A | 9 | 14.2 (13.3–15.1) | ||||
| 15 | rs2078267 | 0.48 | T/T | 23 | 16.6 (15.2–18.1) | 0.020 |
| T/C | 53 | 16.4 (15.7–17.1) | ||||
| C/C | 19 | 12.8 (12.1–13.5) | ||||
| 16 | rs528211 | 0.35 | G/G | 39 | 15.8 (14.9–16.7) | |
| G/A | 46 | 16.0 (15.2–16.8) | ||||
| A/A | 10 | 13.8 (12.7–14.9) | ||||
| 17 | rs11231825 | 0.01 | A/A | 93 | 15.7 (15.1–16.3) | |
| A/C | 2 | 13.4 | ||||
| C/C | 0 | – | ||||
| 18 | rs893006 | 0.35 | T/T | 39 | 15.8 (14.9–16.7) | |
| T/G | 46 | 16.1 (15.3–16.9) | ||||
| G/G | 10 | 13.4 (12.5–14.5) | ||||
| 19 | rs476037 | 0.09 | C/C | 77 | 15.5 (14.9–16.2) | |
| C/T | 18 | 16.1 (15.1–17.2) | ||||
| T/T | 0 | – | ||||
*
rs number as in the NCBI database SNP.
†
MAF, Minor allele frequency.
‡
ClTor, renal torsemide clearance in ml min−1, the geometric mean ± SEM is given.
§
P-values of respective linear regression analyses are given when P < 0.05.