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Cumulative excretion of tizanidine and its metabolites (mean ± SD) into urine (A) and the tizanidine to metabolite 24 h excretion ratios in urine (B) after a single dose of 4 mg tizanidine during the placebo (○ and white bars) and rofecoxib 25 mg day−1 (• and black bars) phases. *P < 0.05; **P < 0.01; ***P < 0.001 vs. placebo
