Table 2.
Escitalopram and demethylescitalopram Cmax, Tmax and Cav for milk and plasma and their M/PAUC values
| Milk | Plasma | ||||||
|---|---|---|---|---|---|---|---|
| Patient | Cmax (µg l−1) | Tmax (h) | Cav (µg l−1) | Cmax (µg l−1) | Tmax (h) | Cav (µg l−1) | M/PAUC |
| Escitalopram | |||||||
| 1 | 64 | 2.8 | 47 | 38 | 1.5 | 28 | 1.7 |
| 2 | 82 | 5.1 | 56 | 41 | 5.4 | 25 | 2.2 |
| 3 | 168 | 2.1 | 99 | 72 | 1.9 | 49 | 2.0 |
| 4 | 57 | 5.9 | 39 | 23 | 4.1 | 18 | 2.0 |
| 5 | 84 | 8.7 | 53 | 37 | 4.9 | 28 | 1.9 |
| 6 | 73 | 11.3 | 58 | 39 | 2 | 25 | 2.3 |
| 7 | 57 | 4.9 | 27 | 15 | 3.3 | 9 | 2.7 |
| 8 | 37 | 10.3 | 28 | 15 | 3.4 | 12 | 2.4 |
| Mean (95% CI) | 78 (51, 105) | 5.5 (4.4, 9.1)* | 51 (35, 67) | 35 (22, 48) | 3.4 (2.0, 4.3)* | 24 (15, 33) | 2.2 (2.0, 2.4) |
| Demethylescitalopram | |||||||
| 1 | 36 | 1 | 28 | 9 | 1 | 20 | 2.3 |
| 2 | 29 | 2.1 | 25 | 11 | 5.4 | 23 | 2.4 |
| 3 | 41 | 2.1 | 49 | 14 | 3.9 | 31 | 2.3 |
| 4 | 22 | 5.9 | 18 | 10 | 7.1 | 18 | 1.9 |
| 5 | 19 | 8.7 | 28 | 7 | 4.9 | 13 | 2.0 |
| 6 | 26 | 4.7 | 25 | 14 | 4.2 | 23 | 1.8 |
| 7 | 27 | 4.8 | 10 | 9 | 4.3 | 18 | 2.1 |
| 8 | 17 | 16.1 | 12 | 6 | 2.1 | 15 | 3.1 |
| Mean (95% CI) | 27 (21, 33) | 4.8 (2.1, 6.6)* | 24 (16, 32) | 10 (8, 12) | 4.3 (3.5, 5.0)* | 20 (16, 24) | 2.2 (1.9, 2.5) |
Median (25th and 75th percentiles).