Skip to main content
. 2006 Apr 21;62(3):316–322. doi: 10.1111/j.1365-2125.2006.02659.x

Table 2.

Escitalopram and demethylescitalopram Cmax, Tmax and Cav for milk and plasma and their M/PAUC values

Milk Plasma
Patient Cmax (µg l−1) Tmax (h) Cav (µg l−1) Cmax (µg l−1) Tmax (h) Cav (µg l−1) M/PAUC
Escitalopram
1  64  2.8 47 38 1.5 28 1.7
2  82  5.1 56 41 5.4 25 2.2
3 168  2.1 99 72 1.9 49 2.0
4  57  5.9 39 23 4.1 18 2.0
5  84  8.7 53 37 4.9 28 1.9
6  73 11.3 58 39 2 25 2.3
7  57  4.9 27 15 3.3  9 2.7
8  37 10.3 28 15 3.4 12 2.4
Mean (95% CI)  78 (51, 105)  5.5 (4.4, 9.1)* 51 (35, 67) 35 (22, 48) 3.4 (2.0, 4.3)* 24 (15, 33) 2.2 (2.0, 2.4)
Demethylescitalopram
1  36  1 28  9 1 20 2.3
2  29  2.1 25 11 5.4 23 2.4
3  41  2.1 49 14 3.9 31 2.3
4  22  5.9 18 10 7.1 18 1.9
5  19  8.7 28  7 4.9 13 2.0
6  26  4.7 25 14 4.2 23 1.8
7  27  4.8 10  9 4.3 18 2.1
8  17 16.1 12  6 2.1 15 3.1
Mean (95% CI) 27 (21, 33)  4.8 (2.1, 6.6)* 24 (16, 32) 10 (8, 12) 4.3 (3.5, 5.0)* 20 (16, 24) 2.2 (1.9, 2.5)
*

Median (25th and 75th percentiles).