Table 3.
Maternal dose of escitalopram, absolute and relative infant doses, and infant plasma concentrations of escitalopram and demethylescitalopram
| Escitalopram | Demethylescitalopram | |||||||
|---|---|---|---|---|---|---|---|---|
| Patient | Maternal dose (µg kg−1 day−1) | Total relative infant dose*(%) | Absolute infant dose (µg kg−1 day−1) | Relative infant dose (%) | Infant plasma concentration (µg l−1) | Absolute infant dose (µg kg−1 day−1) | Relative infant dose*(%) | Infant plasma concentration (µg l−1) |
| 1 | 179 | 7.0 | 3.9 | ND | 3.2 | 1.8 | ND | 5.7 |
| 2 | 139 | 8.3 | 6.0 | <5 | 3.6 | 2.6 | <3 | 6.1 |
| 3 | 235 | 14.9 | 6.3 | <3 | 4.6 | 2.0 | <2 | 8.3 |
| 4 | 299 | 5.8 | 1.9 | ND | 2.7 | 1.0 | ND | 2.9 |
| 5 | 180 | 8.0 | 4.5 | ND | 2.0 | 1.1 | ND | 5.6 |
| 6 | 267 | 8.7 | 3.3 | <1 | 3.4 | 1.3 | <1 | 4.6 |
| 7 | 143 | 4.1 | 2.9 | 3 | 2.7 | 2.0 | 2 | 4.8 |
| 8 | 154 | 4.3 | 2.8 | <1 | 2.3 | 1.5 | <1 | 4.3 |
| Mean (95% CI) | 199 (157, 241) | 7.6 (5.2, 10.0) | 3.9 (2.8, 5.0) | 3.0 (2.4, 3.6) | 1.7 (1.3, 2.1) | 5.3 (4.2, 6.4) | ||
*
Expressed in escitalopram equivalents. ND, No plasma sample available.