Table 2.
Pharmacokinetic parameters of mycophenolic acid in renal transplant patients given mycophenolate mofetil 1.0 g bid
| Sex | AUC (µg h−1 ml−1) | AUMC (µg h−1 ml−1) | tmax (h) | Cmax (µg ml−1) | MRT (h) | CL/F (l h−1) |
|---|---|---|---|---|---|---|
| Male | 48.34 ± 12.32 | 179.98 ± 58.31 | 1.15 ± 0.39 | 16.99 ± 6.35 | 3.67 ± 0.56 | 19.59 ± 2.98 |
| Female | 56.80 ± 11.47 | 204.45 ± 45.79 | 1.0 ± 0.39 | 22.92 ± 9.23 | 3.62 ± 0.54 | 10.92 ± 6.12 |
| Total | 52.16 ± 12.50 | 191.03 ± 53.62 | 1.08 ± 0.39 | 19.67 ± 8.21 | 3.64 ± 0.54 | 15.67 ± 11.19 |
| P-value | 0.06 | 0.21 | 0.30 | 0.04 | 0.82 | 0.02 |
AUC, Area under the concentration–time curve; AUMC, area under the moment curve; tmax, time to maximum concentration; Cmax, maximum concentration; MRT, mean residence time; CL/F, apparent clearance.