Table 2.
High level synthesis of [211At]MABG from a tin precursor anchored to a solid support: Isolation by cation exchange cartridge
| Experiment number | Initial 211At activity used (mCi) | [211At]MABG activity (mCi) in cation exchange cartridge fractions | Radiochemical yield (%)a,b | Final sterile filtered [211At]MABG mCi (%) | |
|---|---|---|---|---|---|
| 2 – 12 | 4 – 10 | ||||
| 1 | 14.81 | 10.18 | 9.86 | 69 (67) | 7.71 (52) |
| 2 | 13.16 | 9.67 | 8.69 | 74 (66) | 7.15 (54) |
| 3 | 16.65 | 11.96 | 10.96 | 72 (66) | 9.12 (55) |
| 4 | 2.23 | 1.36 | 1.22 | 61 (55) | 1.08 (49) |
| 5 | 3.35 | 1.59 | 1.51 | 51 (48) | 1.22 (39) |
| 6 | 17.30 | 11.36 | 10.74 | 66 (62) | 9.19 (53) |
| 7 | 11.16 | 7.19 | 6.96 | 64(62) | 5.82 (52) |
| 8 | 0.39 | 0.26 | 0.25 | 68 (64) | 0.24 (62) |
| 9 | 17.80 | 8.63 | 8.12 | 49 (46) | 6.67 (38) |
| 10 | 16.12 | 9.10 | 8.63 | 56 (54) | 7.45 (46) |
|
| |||||
| Mean±SD | 11.30±6.75 | 63±9 (59±8) | (50 ± 7) | ||
aPercent of initial 211At activity that was eluted in all of the fractions; values in parenthesis is based on the activity eluted in just fractions 4-10.
bSterile filtered fractions 4-10 combined.