Table 6.
Titration Schedule for Basal and Prandial Insulin [6]
| Blood Glucose Levels for 3 Consecutive Days (Fasting, Preprandial, or Bedtime) | Adjust Basal Insulin Dose (U)* | Adjust Rapid-Acting Insulin Dose (U per Injection) |
| ≥180 mg/dL | +8 | +3 |
| 160–180 mg/dL | +6 | +2 |
| 140–160 mg/dL | +4 | +2 |
| 120–140 mg/dL | +2 | +1 |
| 100–120 mg/dL | +1 | Maintain dose |
| 80–100 mg/dL | Maintain dose | - 1 |
| 60–80 mg/dL† | - 2 | - 2 |
| < 60 mg/dL† | - 4 | - 4 |
| Comments: | • For elevated fasting blood glucose levels, adjust only the basal insulin dose | • For elevated preprandial blood glucose at lunchtime, adjust breakfast rapid-acting insulin dose • For elevated preprandial blood glucose at dinnertime, adjust lunchtime rapid-acting insulin dose • For elevated bedtime blood glucose, adjust dinnertime rapid-acting insulin dose |
*Copyright © 2003 American Diabetes Association from Diabetes Care, Vol. 26, 2003; 3080–3086. Modified with permission from The American Diabetes Association.
†If any single blood glucose measurement is in this range, make the appropriate reduction in insulin dose.