Table 1.
Diabetes-related genes. Genes with multivariate expression patterns discovered by the RIT algorithm for the diabetes data.
| Gene | Status | Function | Ref. (PMID) |
| Bcat1 | D | Candidate gene for the type I diabetes susceptibility locus Idd6. | 14563018 |
| Clca2 | N | Chloride channel. Multiple functions, colocalizes with adhesion molecule integrin β4. | 15707651 |
| Clcn1 | N | Chloride channel. Regulates electric excitability of the skeletal muscle membrane. | 7735894 |
| Cltb | D | Involved in insulin receptor internalization. | 7821727 |
| Dopey1 | N | Involved in Golgi/ER vesicle traffic. | 1630131 |
| Epha7 | N | Ephrin receptor subfamily. Ephrin receptors are associated with the pancreatic islets. | 15681844 |
| Hcap-G | N | Chromosome condensation protein, member of the condensin complex. | 14593730 |
| Kcng1 | D | Potassium channel. Potassium channels are involved in regulation of insulin secretion. | 16567526 |
| Loc51152 | N | Melanoma antigen. | |
| Psmal | D | Glutamate carboxypeptidase. Inhibition prevents long-term type 1-diabetic neuropathy. | 11809162 |
| Sox5P | N, T | Transcription factor activity (GeneOntology). Related to the sex determining region Y-gene. | |
| Sptlc2 | N | Sphingolipid biosynthesis enzyme, upregulated upon transepidermal water loss. | 12445191 |
| Ssx2 | N, T | Suggested role as transcriptional repressor. | 12007189 |
| Tfap2B | D, T | Genetic variations in this gene are associated with type 2 diabetes. | 15940393 |
| Usp9Y | N | Associated with male infertility and Sertoli cell-only (SCO) syndrome. | 12871878 |
| Zf | N, T | Specific inhibitor of the transcription factor Luman. Inhibits herpes virus replication. | 16282471 |
Status column: D, diabetes-related; N, novel; T, transcription factor.