Figure 4. Sensitivity of Receptor Function to Extracellular Volume.

The increase in internalized ligand following a ligand impulse is plotted as a function of time for various extracellular volumes for EGFR (A), TfR (B), LDLR (C), and VtgR (D). The volume V was varied as indicated in Figure 4, while all other parameters were set equal to the values listed in Table 1. The arrow in (A) denotes the direction of increasing volume.