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. 2007 Jun 1;3(6):e87. doi: 10.1371/journal.pgen.0030087

Figure 3. Putatively Higher Affinity Binding by ER Is Associated with the ERE.

Figure 3

(A) ChIP-PET ER binding sites are validated by conventional ChIP followed by quantitative PCR. Data shown represent average of duplicate experiments. Binding sites are considered validated if the binding ratio (ER ChIP/irrelevant antibody control) ≥ 2. Validated sites are grouped by presence of EREs (allowing for up to two base deviation from consensus), half ERE sites, and no ERE motifs.

(B) The frequency of ERE motifs increase as the size of binding site clusters increase. ERE motifs are only present in 7.05% similarly sized genomic fragments shown as the background.