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. 2007 Jun 1;3(6):e87. doi: 10.1371/journal.pgen.0030087

Figure 5. Comparison of ER Binding Sites Discovered by ChIP-PET and Published ChIP-on-Chip Experiments Indicate Sites Common to Both Technologies and Platform-Form Specific Sites.

Figure 5

(A) In human Chromosome 21 and 22 studies, 57 ER binding sites were discovered by Carroll et al. [15], and 36 sites were identified in this study. There is an overlap of 20 sites between the two studies.

(B) Validation of select binding sites from both studies by ChIP and qPCR suggest that the common sites (both) are high affinity sites, whereas sites unique to each technology tend to have more moderate affinity for ER.

(C) Venn diagram of the overlap between the 3,665 sites discovered by Carroll et al. and the 1,234 sites identified in this study. The 624 binding sites identified in this study actually correspond to 633 binding regions reported by Carroll et al. [16].