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. 2007 Jun 1;3(6):e87. doi: 10.1371/journal.pgen.0030087

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© 2007 Lin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Binding site affinity measured by ChIP and qPCR for 22 ChIP-PET sites within 100 kb of E2 responsive genes detected in the microarray studies. Up-regulated genes are denoted in red bars and down-regulated genes in green bars. Each binding site is furthered characterized for the presence of EREs, half EREs, or no EREs.

(B) Locations of binding sites adjacent to up- (blue line) and down- (red line) regulated genes are mapped relative to the transcripts. Relative location to a random set of genes from the UCSC KGs database is included as a reference.