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Quantitative receptor autoradiography demonstrated a marked down-regulation of Y1-binding ([125I]GR231118 binding sites sensitive to BIBO3304) within CA1, CA2, and dentate gyrus (DG); P = 0.0001 for wild-type vs. NPY-tg within CA1, CA2, and dentate gyrus, nonsignificant within CA3. Y2 binding ([125I]PYY3–36 labeling sensitive to BIIE0246) did not differ.
