Table 2.

Study design and macroscopic observations. (The material numbers refer to those in table 1.)

material	1	2	3	4	5	6	7	8	9	10	total
number of animals	10	10	10	10	10
subcutaneous (s.c.) sites	10	—	10	—	10	—	10	—	10	—	50
intramuscular (i.m.) sites	—	10	—	10	—	10	—	10	—	10	50
visible nodule development (sites)	0	0	0	0	10	10	0	10	0	0	30
sacrifice or death (animals)
4–5 months	0	0	3a	0	0	3
6 months	4	4	7b	4	4	23
8 months	0	0	0	1a+5b	0	6
12 months	6	6	0	0	6	18

^aDeath of the animal.

^bAnimals were euthanized because of the development of handicapping tumours.