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. 2006 Aug 15;3(11):767–775. doi: 10.1098/rsif.2006.0145

Table 4.

Synopsis of the histological findings. (B, Bulk material; NP, nanoparticulate material.)

material 6-month period 12-month period
TiO : NP granuloma granuloma
TiO : B inflammation inflammation
SiO : NP inflammation inflammation
SiO : B inflammation inflammation
PVC : NP granuloma granuloma+fibroblastic proliferation
PVC : B inflammation inflammation
Co : NP preneoplasia neoplasiaa
Co : B inflammation+granuloma preneoplasiaa
Ni : NP neoplasia b
Ni : B neoplasia b
a

Animals were euthanized after eight months.

b

No analysis—animals were euthanized after six months.