Grim19 |
− |
Mitochondrial oxidoreductase involved in electron transport, linked to apoptosis mediated by interferon β and retinoic acid. |
Cyclin A |
− |
Cell cycle regulator that promotes both G1/S and G2/M transitions |
Cyclin D3 |
− |
Cell cycle regulator required for G1/S transition |
Stat 6 |
− |
Transcription factor activated by cytokine signaling through membrane receptors. Mediates anti-apoptotic activity of IL-4. |
GSK-3b |
− |
Proline-directed serine-threonine kinase with multiple substrates, including β-catenin. |
Integrin linked kinase(ILK) |
− |
Serine-threonine kinase, mediates integrin signaling to cell survival through AKT pathway |
Rho-GDI |
− |
GDP dissociation inhibitor, stimulates signaling through Rho, a GTPase that regulates focal adhesions and stress fibers |
SHC |
− |
Adaptor molecule in ras signal transduction |
Cathepsin D |
+ |
Lysosomal protease implicated in caspase independent cell death via autophagy |
PTEN |
+ |
Protein/lipid phosphatase that preferentially dephosphorylates phosphoinositides. Negative regulator of AKT. |