Figure 2.

Glu uptake is regulated by 5-HT and sensitization training. Glu uptake was measured from synaptosomes immediately and 24 h after a 1.5-h treatment in vivo with either 250 or 500 μM 5-HT, or long-term sensitization training (electrical stimulation). Immediately after treatment with either 250 (n = 7) or 500 μM 5-HT (n = 4), Glu uptake was modestly increased. However, 500 μM 5-HT (n = 5) and sensitization training (n = 5) had a large, significant effect on uptake 24 h after treatment. The effects of 500 μM 5-HT and sensitization training were significantly larger than the effect of 250 μM 5-HT 24 h after treatment (n = 4). All increases in Glu uptake were significantly different from no change. An asterisk (*) indicates the change in uptake was significantly (P < 0.05) different from the effect of 250 μM 5-HT.