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. Author manuscript; available in PMC: 2008 Jan 15.

Published in final edited form as: Bioorg Med Chem. 2006 Nov 1;15(2):686–695. doi: 10.1016/j.bmc.2006.10.062

Table 1.

Physicochemical Data and Antifungal Activities of Synthetic Compounds

				IC₅₀ (μg/mL)
Compd	yield %	MP (°C)	formula	Cn	Ca
1				2–15.6^b	2.- >20
2	68%	251–252	C₁₇H₁₄IN·0.3H₂O	>20	>20
5a	81%	204–205	C₁₆H₁₂INO	>20	>20
5b	68%	215–216	C₁₄H₁₅IN₂S	2.5^*	1.0^*
5c	15%	185–186	C₁₆H₁₁ClINS·0.2H₂O	15	2.0
5e	74%	204–205	C₁₇H₁₁IN₂S·2.5H₂O	>20	>20
5f	51%	216–217	C₁₇H₁₄INOS·0.5H₂O	8.0–15>20
5g	64%	203–204	C₁₇H₁₂INO₂S	>20	>20
5h	53%	234–235	C₁₇H₁₃IN₂OS·1.25H₂O	>20	>20
6	84%	237–238	C₁₇H₁₂F₃NO₃S₂·0.2H₂O	>20	10.0
7	30%	182–184	C₂₆H₃₀INS·2.5H₂O	0.5^*	1.0^*
11a	78%	254–255	C₁₃H₉IN₂O₂S	>20	>20
11b	65%	207–208	C₁₄H₁₅IN₂S·3.8H₂O	>20	>20
11c	71%	194–196	C₁₂H₁₀INS	>20	>20
11d	82%	158–160	C₂₂H₂₂INS·1.1H₂O	20	>20
Amphotericin B				0.95	0.25

^*

Data (MIC, μg/ml) provided by Bristol Myers Squibb.

^b

= Previously reported in ref 4 &7