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. Author manuscript; available in PMC: 2008 Jan 15.
Published in final edited form as: Bioorg Med Chem. 2006 Nov 1;15(2):686–695. doi: 10.1016/j.bmc.2006.10.062

Table 3.

Toxicity of Key Compounds

graphic file with name nihms15520f7.jpg

STRUCTURE Toxicity expressed as IC50 (μ g/ml)
Compd X Murine M109a Human Hep 2a Human HuVeca Vero Cells L6 Cytotoxb BrdU Cytotoxb
Compd 1 NH 0.44 <0.18 1.38 3.2 39.3 <0.78
Compd 5b S 1486 355 662 >4.7 >100 4.6
Amph B NT NT NT 6.5 NT NT
a

= Data supplied by Bristol Myers Squibb.

b

= Data supplied by Eli Lilly & Co.