Table 1.
A partial list of genes up-/down-regulated in SGD versus normal bone marrow by Affymetrix Chip analysis
| Fold change | Abbreviation | Genbank accession no. | |
|---|---|---|---|
| Defensin alpha 1 | −3.7 | DEFA1 | NM_004084.2 |
| Defensin alpha 4 | −5.4 | DEFA4 | NM_001925.1 |
| Proteinase 3* | 4.6 | PRTN3 | NM_002777.2 |
| BPI* | 4.3 | BPI | NM_001725.1 |
| Secondary granule proteins | |||
| Neutrophil collagenase | −5.4 | MMP8 | NM_002424.1 |
| Neutrophil gelatinase | −3.5 | MMP9 | NM_004994.1 |
| Transcobalamin 1 | −4.5 | TCN1 | NM_001062.1 |
| Specific granule protein 28 | −9 | SGP28 | NM_006061.1 |
| Neutrophil function | |||
| gp47 phox* | 9.1 | NCF1 | NM_000265.1 |
| gp91 phox* | 6 | CYBB | NM_000397.1 |
| IL-8 | −2 | IL8 | AF043337.1 |
| Leukocyte IgG receptor, FcgR | 4.7 | FCGR | J04162.1 |
| Proteoglycan recognition protein | 13.8 | PGLYRP | NM_005091.1 |
| Transcription factors | |||
| CKLF | 5.6 | CKLF | AF132818 |
| KLF4 | 3.6 | KLF4 | NM_004235 |
| C/EBPδ | 2.1 | C/EBPd | AV655640 |
| C/EBPϵ | 1.5 | C/EBPe | NM_001805 |
| C/EBPα | 1.5 | C/EBPa | NM_004364.1 |
| Hox A9 | 4.3 | HoxA9 | U41813.1 |
| Fox B | 4.1 | FOSB | NM_006732.1 |
| PU.1 | 3.2 | PU.1 | NM_003120 |
| Egr-1 | 1.5 | Egr-1 | NM_001964 |
| Other genes | |||
| Eosinophil cataionic protein | −4.8 | RNASE3 | NM_002935.1 |
| Cathepsin W | −2.5 | CTSW | NM_001335.1 |
| Cathepsin D | 3.2 | CTSD | NM_001909.1 |
| CD11b* | 5 | ITGAM | NM_000632.2 |
| CD18* | 4.1 | Mac-1B | NM_000211.1 |
| GM-CSF receptor* | 2.7 | CSF2RA | NM_006140.1 |
| TGFb1 | 3.4 | TGFB1 | NM_000358.1 |
| Calpain-3 | 3.1 | p94 | BC003169.1 |
*
Known PU.1 regulated genes.