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Reintroduction of Pbx1b in Pbx1−/− ES cells restores B-cell and CLP development in Rag1-deficient blastocyst-complemented mice. (A) FACS analysis shows the presence of IgM+B220+ B cells and normal numbers of TCRαβ+ cells in the peripheral blood of mice chimeric for Pbx1b-rescued ES cells at levels comparable with Pbx1+/+Rag1−/− control mice. (B) FACS analysis shows that donor-derived (Ly9.1+) CLPs are present in Pbx1−/−RRag1−/− chimeras.
