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Deletion of GR in macrophages augments LPS-induced lethality and proinflammatory responses. (A) Kaplan-Meier plot of control (n = 8) and MGRKO (n = 8) mice treated with LPS (10 mg/kg). P < .01 for MGRKO versus control. (B) Plasma concentrations of TNF-α and IL-6 in control (n = 7-10) and MGRKO (n = 6-10) mice treated with LPS for the indicated periods of time. Error bars indicate SEM.
