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Dex selectively suppresses LPS-mediated activation of p38 MAPK. (A) Time-dependent effect of LPS (100 ng/mL) on p38 MAPK phosphorylation. Representative of 2 independent experiments. Effect of Dex (100 nM) on LPS-mediated phosphorylation of (B) p38 MAPK in control and MGRKO macrophages and (C) JNK (p46/p54), (D) ERK1/2, or (E) Akt in the control macrophages. Representatives of 3 to 4 independent experiments.
