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. Author manuscript; available in PMC: 2008 Jan 1.

Published in final edited form as: Clin Dermatol. 2007;25(1):79–92. doi: 10.1016/j.clindermatol.2006.09.011

Gene delivery to cells and tissues expands the range of targets. Traditional wound therapy with biomacromolecules such as growth factors (GF) relies on the interaction of the signal with a cell surface receptor, which then transmits its signal to the nucleus to activate gene expression. Gene expression profiling has shown that surface receptors, intracellular signal pathways (transducers), and factors that directly interact with the genetic machinery (transcription factors) are also modulated during the healing process. These intracellular signals are prime candidates for gene delivery methods.

Gene delivery to cells and tissues expands the range of targets. Traditional wound therapy with biomacromolecules such as growth factors (GF) relies on the interaction of the signal with a cell surface receptor, which then transmits its signal to the nucleus to activate gene expression. Gene expression profiling has shown that surface receptors, intracellular signal pathways (transducers), and factors that directly interact with the genetic machinery (transcription factors) are also modulated during the healing process. These intracellular signals are prime candidates for gene delivery methods.