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UVB irradiation leads to an intracellular formation of FICZ. Identification of the Trp-photoproduct FICZ by HPLC-MS: Trp-starved cells were incubated with 1 mM [13C1115N2]Trp (labeled with ∗) 1 h before irradiation with 60 mJ/cm2 UVB. Control cells were sham irradiated. After 10 min, cells were harvested, and cell extracts were prepared for HPLC-MS-MS analyses. The mass analysis revealed the occurrence of [13C15N]FICZ (arrow) with the expected mass of 305.3.
