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AhR KO mice show a decreased UVB responsiveness. Dorsal skin of wild-type and AhR KO C57BL/6 mice was shaved 24 h before exposure. Mice were irradiated dorsally with a single exposure of UVB (20 min 40 sec; 600 J/cm2). Twelve hours after irradiation, mice were euthanized, and skin samples were excised. RT-PCR analyses indicate an AhR dependence of Cyp1a1 and Cox-2 mRNA induction in UVB-irradiated mouse skin.
