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A proposed model showing the selective recruitment of adaptor proteins by Flk-1 and the differential signaling pathways regulating ERK and JNK in response to VEGF and shear stress. VEGF induces the Flk-1·Nckβ association to regulate ERK and JNK activation (broken arrows), whereas shear stress regulates ERK through Flk-1 and Cbl, but activates JNK through Src and ROCK (solid arrows) independent of Flk-1. The dashed arrows represent possible actions of VEGF on Src and ROCK.
