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Chromosome change-associated up-regulation of uPA contributes to the invasive phenotype of A2-BH7. (A) Changes in A2-BH7 versus DB-A2 cells in chromosome number and chromosome transcriptome. (B) Northern blot analysis showing up-regulation of uPA in BH7 cells. (C) The uPA inhibitor, B428, blocked HGF-induced cell invasion through Matrigel. Cells (10,000 per insert) were loaded into Matrigel inserts and treated with 10 μM B428 or left untreated (controls, C) for 1 h before adding HGF/SF.
