Fig. 1.

Analysis of separate hyperplastic nodules with and without oncocytic phenotype from the same thyroid (case HTC1, Table 1). (Upper) Histologic appearance of the hyperplastic oncocytic nodule (A) and of one hyperplastic nodule without oncocytic change (B). Immunohistochemistry with antibodies specific for human mitochondria confirms the increased mitochondrial mass in the oncocytic nodule (C) compared with the nononcocytic one (D). (Lower) The heteroplasmic nonsense mutation of the ND5 (G13414A) gene in the oncocytic and nononcocytic nodule. (Magnification: ×400.)