Fig. 2.

Disruptive mtDNA mutation in a mitochondrion-rich breast carcinoma (case BRCA13, Table 1). (A) Electropherograms showing the heteroplasmic deletion in the ND1 gene in tumor (Upper) and perilesional normal (Lower) tissue. (B) Histologic appearance of the breast carcinoma showing neoplastic cells with abundant eosinophilic cytoplasm and oncocytic features. (C and D) Immunohistochemistry with antibodies specific for human mitochondria confirms the increased mitochondrial mass in the tumor (D) compared with the nonneoplastic perilesional breast parenchyma (C). (Magnification: ×400.)