Table 1.
β-Catenin Mutation in Relation to Chronic Hepatitis B and C Virus Infection in 366 Patients with Unifocal and 55 Patients with Multifocal Primary Hepatocellular Carcinoma
| β-Catenin mutation in HCC (+, %) | P value | |||
|---|---|---|---|---|
| Unifocal | Multifocal | Total | ||
| HBV | ||||
| (+)* | 27/276 (9.8) | 3/47 (6.4)† | 30/323 (9.3)‡ | <0.00001 |
| (−) | 20/90 (22.2) | 7/21 (33.3)† | 27/111 (24.3)‡ | |
| Total | 47/366 (12.8) | 10/68 (14.7) | 57/434 (13.1) | |
| HBV(−) | ||||
| Anti-HCV(+) | 17/74 (23.0) | 6/18 (33.3) | 23/92 (25.0) | NS |
| Anti-HCV(−) | 3/16 (18.8) | 1/3 (33.3) | 4/19 (21.0) | |
*HBV, HCC positive for hepatitis B virus surface antigen or HBV genome in HCC and/or nontumor liver tissues. Anti-HCV, hepatitis C virus antibody in serum. The denominator designates number of tumor nodules examined.
†This includes 34 patients who were positive for serum HBsAg or had HBV genome in liver tissues, or both, and 21 patients negative for HBV.
‡Fisher exact test, two-tailed.