Table 3.
Correlation of β-Catenin Mutation with Clinicopathological Features in 366 Patients with Unifocal Primary Hepatocellular Carcinoma
| Feature | β-Catenin mutation | P value | |
|---|---|---|---|
| Present, n = 47 (%) | Absent, n = 319 (%) | ||
| Mean age (year) | 61.6 ± 11.0 | 54.7 ± 13.4 | 0.0009 |
| Gender: Male | 42 (89.4) | 249 (78.1) | NS |
| HBsAg in serum: (+) | 22 (46.8) | 228 (71.5) | 0.0013 |
| Serum AFP ≥ 320 ng/ml | 8 (17.0) | 155 (48.6) | <0.00001 |
| Mean tumor size (cm) | 6.31 ± 3.67 | 7.06 ± 4.49 | NS |
| Tumor grade* | |||
| I | 21 (44.7) | 69 (21.6) | 0.005† |
| II | 14 (29.8) | 131 (41.1) | |
| III | 12 (25.5) | 119 (37.3) | |
| Tumor stage* | |||
| I | 24 (51.2) | 56 (17.6) | <0.0001† |
| II | 10 (21.3) | 73 (22.9) | |
| IIIA | 7 (14.9) | 60 (18.8) | |
| IIIB | 5 (10.6) | 45 (14.1) | |
| IV | 1 (2.1) | 85 (26.6) | |
Abbreviations: HBsAg, hepatitis B surface antigen; AFP, serum α-fetoprotein level.
*See Materials and Methods for details.
†Fisher exact test, two-tailed.