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. 2000 Sep;157(3):1017–1029. doi: 10.1016/S0002-9440(10)64614-7

Figure 5.

Figure 5.

Figure 5.

Placenta malformation and fetal distress in ABCA1−/− mice. A: Placental labyrinth from day 14 of gestation was immunostained with anti-CD71 (specific for trophoblasts). Placentas were ABCA1+/+ (left) and 64.7 ABCA1−/− (right). Original magnification, ×100. B: Placental labyrinth from day 14 of gestation was H&E stained. Placentas were ABCA1+/+ (left), ABCA1+/− (middle), and ABCA1−/− (right). Original magnification, ×63. L, labyrinth; S, spongiotrophoblast; D, deciduae; n = 20 ABCA1−/−, 13 ABCA1+/−, and 22 ABCA1+/+ placentas assayed. C: Intrauterine growth retardation of 64.7 ABCA1−/− embryos. Embryos at gestation day 14 were collected from an ABCA1−/− cross and are arranged by size. Sizes of the ABCA1−/− embryos vary from normal (top left) to resorption (bottom). D: Brown-stained amniotic sac observed in ABCA1−/− (right) but not ABCA1+/+ (left) embryos at day 19 gestation. E: Placenta labyrinth from ABCA1+/+ (left), ABCA1+/− (middle), and ABCA1−/− (right) day 19 gestation embryos was H&E stained. Original magnification, ×63. L, labyrinth; S, spongiotrophoblast; D, deciduae; n = 4 ABCA1−/−, 5 ABCA1+/−, and 7 ABCA1+/+ placentas. F: Resorbing embryos were collected from ABCA1+/+ (left) or ABCA1−/− (right) cross at day 19 of gestation. G: Resorbing placenta from ABCA1+/+ (left) or ABCA1−/− (right) embryos at day 19 of gestation were H&E stained. Original magnification, ×100.