Table 3.

Clinical, Histological, Immunohistochemical, and Histochemical Factors Related to Survival in 292 Clinical Stage I Cutaneous Malignant Melanoma

Category (variable)	No. of patients	5-year RFS (95% CI)	P*	5-year OS (95% CI)	P*
Sex			0.0292		0.0339
Male	143	0.69 (0.60–0.76)		0.81 (0.73–0.87)
Female	149	0.80 (0.73–0.86)		0.90 (0.83–0.94)
Bleeding			0.0001		0.0001
Yes	76	0.65 (0.52–0.75)		0.80 (0.68–0.88)
No	119	0.86 (0.78–0.91)		0.93 (0.86–0.97)
Unknown	97	0.69 (0.59–0.78)		0.81 (0.71–0.88)
Clark’s level			<0.00005		0.0001
I	12	0.88 (0.39–0.98)		0.88 (0.39–0.98)
II	54	0.98 (0.88–1.0)		0.98 (0.87–1.0)
III	82	0.79 (0.68–0.87)		0.93 (0.84–0.97)
IV	119	0.63 (0.54–0.71)		0.79 (0.70–0.86)
V	25	0.61 (0.38–0.78)		0.63 (0.39–0.80)
Tumor thickness (mm)			<0.00005		<0.00005
≤0.75	64	0.97 (0.87–0.99)		0.96 (0.86–0.99)
0.76–1.50	69	0.79 (0.66–0.87)		0.93 (0.82–0.97)
1.51–4.0	99	0.67 (0.57–0.76)		0.82 (0.72–0.88)
>4.0	41	0.48 (0.31–0.63)		0.60 (0.40–0.75)
TNM category			<0.00005		<0.00005
pT1-T2, N0, M0	131	0.91 (0.85–0.95)		0.96 (0.90–0.99)
pT3, N0, M0	115	0.66 (0.56–0.74)		0.81 (0.73–0.88)
pT4, N0, M0	46	0.52 (0.36–0.66)		0.63 (0.44–0.77)
CD44			0.0001		0.0077
≤90%	153	0.67 (0.59–0.74)		0.81 (0.74–0.87)
>90%	129	0.83 (0.75–0.88)		0.89 (0.82–0.94)
Cellular HA			0.0141		0.0146
≤70%	140	0.69 (0.61–0.76)		0.82 (0.74–0.87)
>70%	137	0.78 (0.70–0.84)		0.88 (0.80–0.93)

RFS, recurrence free survival; OS, overall survival; CI, confidence interval; HA, hyaluronan.

*Log rank analysis.