Table 1.
Clinical and Genetic Data of 32 Well-Differentiated Neuroendocrine Tumors and Three Associated Metastases
| No. | Age/ sex | Diagnosis | Metastasis | Size (cm) | CGH finding | FISH finding | |||
|---|---|---|---|---|---|---|---|---|---|
| Gain | Loss | 18c | 11q13 | 11q13.4-q21 | |||||
| 1 | 73 /m | BNET | Liver, spleen | 4.5 | +17q24-qter | −6q14-qter, −11q13-qter | L | ||
| 2 | 68 /f | BNET | nk | 3 | +7p,+7q, +17p,+17cen-q21 | −1p,−11q13-qter | L | L | |
| 3 | 34 /f | BNET | nk | 4.8 | +5p,+5q24-qter, +14q24-qter | ndc | ndc | ||
| 4 | 72 /f | BNET | nk | 3.2 | +9q,+16q,+20q | ndc | ndc | ||
| 5 | 30 /f | BNET | nk | 2.5 | ndc | ndc | |||
| 6 | 44 /m | BNET | nk | 1.4 | +5p,+5q,+8p,+8q, +16q | ndc | ndc | ||
| 7 | 47 /f | BNET | nk | 1.3 | +9q34 | −15q,−22q | ndc | ndc | |
| 8 | 45 /f | BNET | nk | 2 | −11cen-p14, −11q13-qter | ndc | L | ||
| 9 | 45 /m | BNET | nk | 2 | −11p15,−11q13.2-qter | ndc | L | ||
| 10 | 45 /f | BNET | nk | 1 | ndc | ndc | |||
| 11 | 55 /m | BNET | nk | 3 | ndc | ndc | |||
| 12 | 42 /f | GINET | Local LN | nk | −18p,−18q | ndc | |||
| 13 | 68 /f | GINET | Local LN | 1 | −16q13-q24,−18p, −18q | L | |||
| 14# | 63 /f | GINET Area 1 | Local LN | 2 | L* | ||||
| Area 2 | 2 | −18p,−18q | L | ||||||
| 15 | 26 /f | GINET | Liver | 5 | +9q34,+17p,+17q | −1q22-qter | |||
| 16 | 79 /m | GINET | Local LN | 1 | −18p,−18q | L | |||
| 17 | 89 /f | GINET | Local LN | 4 | −18p,−18q | L | |||
| 18 | 70 /f | GINET | nk | +10p,+10q | −18q22-qter | ||||
| 19# | 70 /m | GINET | LN | 2 | |||||
| 20 | 38 /f | GINET | Local LN | 0.7 | |||||
| 21 | 16 /f | GINET | 3.5 | +9q34 | ndc | ||||
| 22 | 19 /f | GINET | Local LN | 2 | |||||
| 23 | 53 /m | GINET | 10 | +17p,+17q | |||||
| 24 | 50 /m | GINET | Liver and LN | 2.5 | +1q,+7p,+7q,+15q,+10q22-qter,+20q | −3q21-qter, −y | |||
| 25 | 55 /m | GINET | LN | 12 | +3p,+3q,+9p13-pter, +9q21-qter | −10p,−10q,−13q,−16p,−16q,−17p,−18p,−18q, −21q,−22q | |||
| 26 | 68 /m | GINETα | Liver | 1.5 | |||||
| 27 | 73 /f | GINETα | Local LN | 2 | |||||
| 28 | 27 /m | GINETα | nk | nk | |||||
| 29# | 70 /m | GINETα | nk | ndc | |||||
| 30 | 68 /f | GINETα | nk | ||||||
| 31 | 65 /f | GINETα | Local LN | 1 | −1q13.2-qter, −18p,−18q | L | |||
| 32 | 65 /m | GINETα primary | nk | ||||||
| metastasis | Stomach | nk | −3p,−3q | ||||||
| 33 | 35 /f | NET’s metastasis | Liver | 10 | +4p,+4q, +20q | −9p21-qter,−13q21-q22,−16q21-qter,−18p,−18q | L | ||
| 34 | 46 /m | NET’s metastasis | Paraortal LN | 4 | +5p, +5q,+7p,+7q | ||||
#Two or three different regions of the tumors were examined for genetic heterogeneity; m, male; f, female; BNET, bronchial neuroendocrine tumors; GINET, gastrointestinal neuroendocrine tumors; α, mixed endocrine-exocrine tumors; nk, not known; LN, lymph node; ndc, no detectable change; L, loss; 18c, centromere 18 probe; 11q13, MEN1 gene; 11q13.4-q21, cClll-270.
*Deletion of chromosome 1 was also detected, suggesting monosomy.