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Inactivation of the p53 pathway in HPDE6-E6E7c7 cells. A: These cells showed low-level expression of wild-type p53 protein as recognized by both pAb 421 and pAb 1802 but not by pAb 240 antibodies. B: Irradiation with γ-ray failed to induce p53 and p21 proteins in HPDE6c7 cells. As control, normal bronchial epithelial cells showed the normal response to γ-irradiation.
