Table 2.
Estimated Chromosome Copy Number Based on Combined Information of Number of Centromeric Signals Found Using FISH at Interphase Nuclei and Tumor Percentage (Shown in Italics)
Chromosome | Probe | Repetitive family | Reference no. | Case | ||||
---|---|---|---|---|---|---|---|---|
114 | 408 | 178 | 262 | 215 | ||||
tum%: | 95% | <50% | 80% | 75% | 70% | |||
1 | pUC1.7 | Satellite III | 63 | 1 | 1* | 2 and 4 | 2 | 2 |
3 | pα3.5 | Alphoid satellite | 64 | NS | NS | NS | 2 | 2 |
6 | p308 | Alphoid satellite | 65 | 1 | 1* | 1 and 2 | 2 | 2 |
7 | p7t1(αp7) | Alphoid satellite | 66 | 1 | 2 | 2 and 4 | 2 | 3* |
8 | D8Z2 (αp8) | Alphoid satellite | 67 | 1 | 1* | 2 and 4 | 2 | 3* |
9 | pHUR98 (sp9) | Satellite III | 68 | 1 | 2 | 2 and 4 | 2 | 2 |
10 | D10Z1 (αp10) | Alphoid satellite | – | 1 | 1* | 1 and 2 | 2 | 2 |
11 | pLC11A | Alphoid satellite | 69 | 1 | 1* | 1 and 2 | 2 | 2 |
12 | pα12H8 (αp12) | Alphoid satellite | 70 | 2 | 2 | 2 and 4 | 4 | 2 |
15 | D15Z1 | Satellite III | 71 | 2 | 2 | 2 and 4 | 2 | 4* |
16 | pHUR195 | Satellite II | 68 | 1 | 1* | 2 and 4 | 2 | 2 |
17 | p17H8 | Alphoid satellite | 72 | 1 | 1* | 2 and 4 | 2 | 3* |
18 | L1.84 (#18) | Alphoid satellite | 73 | 1 | 2 | 2 and 4 | 2 | 2 |
20 | p3.4 | Alphoid satellite | – | 1 | 2 | NS | 4 | NS |
X | pBAMX5 (αpX) | Alphoid satellite | 74 | 1 | 1 | 1 and 2 | 4 | 1* |
Y | DYZ3 | Alphoid satellite | 75 | 1 | 0 | 0 | 0 | 0 |
*Many nuclei show two copies of the chromosomes, because of a high percentage of nontumor nuclei. NS: nonsuccessful hybridization.