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. 2000 Dec;157(6):1937–1945. doi: 10.1016/s0002-9440(10)64832-8

Figure 5.

Figure 5.

Effect of MAPKK inhibition on TIMP bioactivity. The first graph examines the effect of acute inhibition of MAPKK by addition of PD98059 on TIMP bioactivity. This experiment was repeated in triplicate. Lane 1 represents vehicle-treated cells; lane 2 represents cells treated with PD98059. The second graph examines the effect of chronic inhibition of MAPKK (SVRA221a) by stable expression of dominant negative MAPKK. Lane 3 represents SVRbag4 (vector control cells), and lane 4 represents conditioned media from an equivalent number of SVRA221a cells.