Table 3.

Transplanted Hepatocyte Cell-Doubling Characteristics

Time after transplant	Mean focus area (mm2)*	Mean focus volume (mm3)†	Mean cell number‡	Cumulative cell doublings§	Mean cell doubling time
1 week	0.007	0.00048	58	5.8	29 hours
2 weeks	0.04	0.0062	760	9.5	45 hours
4 weeks	0.09	0.020	2,400	11.2	200 hours
8 weeks	0.13	0.040	4,900	12.2	670 hours

*Data for mean focus cross-sectional area taken from Figure 3 ▶ for 2- to 4-month-old donor cell preparations.

^†V = 4/3πr³, taking r as [A/π]^1/2, where A is mean focus cross-sectional area.

^‡Calculated by dividing mean focus volume by mean hepatocyte volume (8.2 × 10⁻⁶ mm³ for a 25-μm-diameter hepatocyte; modified from Sandgren et al 9 ).

^§Number of cell doublings needed to produce the mean cell number entered in column 4 from a single progenitor cell (assumes no cell death).

Calculated by dividing the number of hours in each posttransplant interval by the number of cell doublings for that interval.