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Radiographic progression of CIA in the tibiotarsal joint of rats with CIA. A: There is no evidence of pathology in the tibiotarsal joints of normal rats. B: The hindpaws from CII-immunized (35 days) rats demonstrated bone resorption (arrow). C: Calpain inhibitor I suppressed joint pathology (arrow) and soft tissue swelling in the rat hindpaw. This figure is representative of at least three experiments performed on different experimental days.
