Table 1.
Clinical, Pathological, and Immunohistochemical Features
| Clinical and pathologic features | Immunohistochemical staining (percent positive tumor cells) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient no. | Age | Sex | Eye | LBD (mm) | Location | Thickness (mm) | Pathology | Cytology rank | Prior treatment | Rb | phospho-Rb | p16 | Cyclin D1 | p53 | MDM2 | Bcl-2 |
| 1 | 56 | M | L | 16 | P | 9.2 | Mixed | 24 | None | 58 | 0.4 | 33 | 1 | 0 | 75 | 98 |
| 2 | 79 | F | L | 18 | A | 8.6 | Mixed | 19 | None | 71 | 1.7 | 82 | 58 | 0.2 | 78 | 98 |
| 3 | 28 | M | L | 11 | P | 7.2 | Mixed | 26 | None | 64 | 1.5 | 95 | 1 | 0 | 67 | 99 |
| 4 | 79 | M | L | 24 | P | 10.4 | Mixed | 21 | None | 61 | 0.9 | 97 | 2 | 0.1 | 84 | 99 |
| 5 | 67 | M | R | 16 | P | 2 | Epithelioid | 29 | None | 72 | 1.3 | 82 | 2 | 0 | 75 | 97 |
| 6 | 44 | M | L | 19 | A | 9.6 | Mixed | 16 | None | 74 | 1.1 | 77 | 48 | 0.1 | 65 | 98 |
| 7 | 68 | F | L | 22 | P | 5.5 | Mixed | 7 | None | 66 | ND | 91 | 58 | 0.1 | 68 | 99 |
| 8 | 63 | M | R | 16 | P | 6 | Spindle | 2 | PRT | 19 | 5.8 | 60 | 22 | 0.4 | 74 | 98 |
| 9 | 84 | F | L | 11 | P | 11.1 | Mixed | 6 | None | 71 | 0.9 | 94 | 41 | 0 | 71 | 99 |
| 10 | 66 | M | L | 18 | A | 7.1 | Mixed | 15 | None | 86 | 1.5 | 89 | 23 | 0 | 48 | 98 |
| 11 | 37 | M | R | 15 | A | 8.2 | Spindle | 5 | None | 82 | 0.2 | 70 | 2 | 0 | 65 | 98 |
| 12 | 65 | F | R | 20 | P | 12.6 | Spindle | 1 | None | 63 | 4 | 95 | 20 | 1.1 | 79 | 98 |
| 13 | 73 | M | R | 23 | A | 11.1 | Epithelioid | 32 | None | 59 | 4 | 98 | 3 | 0.1 | 58 | 97 |
| 14 | 70 | M | L | 15 | A | 8.2 | Mixed | 17 | None | 63 | 4.2 | 69 | 19 | 0.1 | 55 | 100 |
| 15 | 77 | M | L | 20 | A | 8 | Epithelioid | 30 | None | 81 | 2.5 | 70 | 64 | 0.1 | 66 | 95 |
| 16 | 79 | F | R | 14 | P | 3.1 | Mixed | 23 | None | 76 | 1.5 | 65 | 1 | 0 | 64 | 98 |
| 17 | 67 | M | L | 12 | P | 3 | Mixed | 9 | PRT | 78 | 7.5 | 95 | 6 | 0 | 76 | 98 |
| 18 | 44 | M | R | 19 | A | 12.2 | Mixed | 18 | None | 53 | 0.4 | 82 | 1 | 0 | 71 | 98 |
| 19 | 82 | M | L | 13 | P | 3.1 | Spindle | 4 | TTT | ND | ND | ND | ND | 0 | ND | 97 |
| 20 | 41 | M | R | 17 | P | 8.9 | Mixed | 20 | None | 24 | 3.6 | 99 | 1 | 0 | 14 | 98 |
| 21 | 51 | F | L | 9 | P | 6.5 | Epithelioid | 31 | None | 64 | 3.1 | 95 | 13 | 0.2 | 75 | 100 |
| 22 | 40 | M | L | 12 | P | 7.7 | Spindle | 3 | None | 68 | 3.8 | 68 | 10 | 0.1 | 64 | 99 |
| 23 | 78 | F | L | 19 | A | 10 | Mixed | 14 | None | 81 | 0.6 | 47 | 60 | 0.1 | 64 | 100 |
| 24 | 52 | F | R | 14 | P | 8.5 | Mixed | ND | None | ND | ND | ND | 1 | 0.1 | 68 | 99 |
| 25 | 76 | F | R | 8 | A | 5 | Mixed | 11 | None | ND | ND | ND | 9 | 0 | 67 | 97 |
| 26 | 75 | M | R | 18 | A | 11 | Mixed | 12 | None | 66 | 3.3 | 80 | 43 | 0 | 64 | 99 |
| 27 | 65 | M | L | 24 | A | 6.2 | Mixed | 13 | None | 73 | 2.3 | 74 | 8 | 0.2 | 63 | 99 |
| 28 | 79 | M | R | 10 | P | 3.5 | Mixed | 25 | TTT | 34 | 1.3 | 31 | 6 | 0.1 | 63 | 99 |
| 29 | 55 | F | L | 20 | A | 10 | Mixed | 27 | None | 92 | 5.6 | 92 | 2 | 0.9 | 78 | 99 |
| 30 | 54 | M | L | 10 | P | 4.8 | Mixed | 22 | None | 67 | 0.6 | 63 | 2 | 0.2 | 66 | 97 |
| 31 | 64 | M | L | 8 | P | 3.1 | Mixed | 28 | None | 73 | 0.2 | 39 | 49 | 0.1 | 66 | 98 |
| 32 | 47 | M | L | 18 | P | 10.8 | Mixed | 10 | PRT | 10 | 0.2 | 67 | 18 | 0.2 | 67 | 99 |
| 33 | 63 | F | R | 9 | P | 5 | Mixed | 8 | None | 76 | 2.9 | 100 | 1 | 0 | 74 | 99 |
M, male; F, female; L, left eye; R, right eye; LBD, largest basal tumor dimension; A, anterior; P, posterior; PRT, plaque radiotherapy (brachytherapy); TTT, transpupillary thermotherapy; ND, not done.