Table 1.

Gene expression comparison of cortex from naïve mice and mice undergoing 3- and 6-h enriched environmental training

Accession no.	Gene name	3 h	6 h
DNA/RNA synthesis
D63902	Estrogen-responsive finger protein	2.2	2.1
AA117835	Myelin gene expression factor	2.1	2.1
AA415044	Polyhomeotic, Hox transcription repressor	5	7
C80883	Hif 1alpha transcription factor	6	7
AA003541	Kinase, regulate DNA replication	3	5
X14805	DNA methyl-transferase	17	10
X66223	Retinoid X receptor α	−26	−16
Neuronal signaling
AA270734	Calmodulin gene III	1.8	1.7
AB006361	Prostaglandin D synthetase	2.1	2.6
D17584	Neurokinin A	2.9	2.6
U27106	Clathrin AP-2	2.2	2.3
U60150	Synaptobrevin	1.9	NC
AA462551	MAP kinase 4K3	5	NC
D78645	Glucose-regulated protein 78	2.6	2
Neuronal growth/structure
AF180805	Microfibril-associated glycoprotein-2	1.9	2.1
AA161790	RhoA gene	3	2.6
AA545177	Microfibrillar protein	3	3
AA416453	Integrin alpha-4	3	3
M93310	Brain specific metallothionein III	−2.5	−1.7
U95116	Lissencephaly-1 protein	−2.4	−2.1
M74773	Brain spectrin	−4	−2.1
U39904	Citron, rho/rac binding protein	−5	−12
AA017811	Neurogranin, calmodulin binding protein	NC	−1.6
Protease/cell death
L22472	Bcl-2 associated protein, Bax	−2.9	−2.5
AA013993	Prolyl oligopeptidase	−2.6	−2.7
AA020512	Caspase-6	−3	−3
M55616	Protease 4	−3	−4
AA154337	Ribosome-associated DnaJ, molecular chaperone	NC	−2.7

Each RNA sample was hybridized twice to two different arrays and fold change values are averages of the duplicate measurements. Positive values indicate an increase in gene expression; negative values indicate a decrease, and no change marked NC.