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. 2007 May 23;8:34. doi: 10.1186/1471-2202-8-34

Table 1.

Expression difference between pools of six narcoleptic dogs and six unaffected siblings, heterozygous for the canarc-1 mutation. Similarity scores (right-most column) between the human gene and the dog orthologue was retrieved from Ensembl v39 (June 2006) and aligned with BLAST (bl2seq).

Clone ID Symbol Name PenF ratio p-value A H P Similarity (%)
2017204 PENK Proenkephalin 11.0 0.0008 -1.36 -0.09 -0.39 87
784179 TAC1 Tachykinin, precursor 1 8.7 0.0025 -1.20 -0.05 -0.44 96
430318 PVALB Parvalbumin 8.3 0.0044 +0.51 +0.91 +0.28 90
824643 CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2, beta 7.0 0.0034 -0.49 -0.57 -0.44 92
782789 AVPR1A Arginine vasopressin receptor 1A 6.3 0.0019 -0.70 -0.21 -0.48 88
843426 SAV1 Salvador homolog 1 (Drosophila) 6.1 0.0022 +0.66 +0.07 +0.64 95
853956 ARIH2 Ariadne homolog 2 (Drosophila) 5.9 0.0064 -0.25 -0.68 -0.48 94
1848986 PCYT1B Phosphate cytidylyltransferase 1, choline, beta isoform 5.7 0.0104 -0.34 -0.56 -0.54 93
825265 POLD3 Polymerase (DNA-directed), delta 3, accessory subunit 5.7 0.0068 +0.45 +0.33 +0.61 90
1535596 RDH11 DKFZP564M1462 protein 5.6 0.0050 -0.40 -0.30 -0.65 88
838504 SMBP SM-11044 binding protein 5.5 0.0066 +0.66 +0.28 +0.42 95
1046495 N/A # 5.5 0.0016 +0.02 -0.85 -0.44 Not found
646753 FLJ38736 Hypothetical protein FLJ38736 5.3 0.0045 -0.47 -0.13 -0.70 87
896949 HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 5.2 0.0066 +0.44 +0.30 +0.56 92
287646 RNF14 Ring finger protein 14 5.1 0.0085 +0.40 -1.62 -0.09 93
1506399 N/A * 5.1 0.0091 -0.52 -0.02 -0.77 Not found
796885 RPL23 Ribosomal protein L23 5.0 0.0063 +0.74 -0.05 +0.59 Not found
45452 N/A † 5.0 0.0308 -0.33 -0.49 -0.74 Not found
898222 ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 4.9 0.0209 -0.38 -0.36 -0.68 88
131073 SOCS2 Suppressor of cytokine signaling 2 4.8 0.0044 -0.79 -0.16 -0.27 97
308231 MYO1B Myosin IB 4.8 0.0049 -0.56 -0.30 -0.37 92
448708 GAPVD1 GTPase activating protein and VPS9 domains 1 4.6 0.0106 +0.58 +0.12 +0.55 Not found

The eight underlined genes have been also tested with qPCR. Average differences between narcoleptics and controls larger than a log2 value corresponding to 0.7 (1.6 fold) are also underlined. N/A = not annotated in the clone database.

# Transcribed locus, moderately similar to NP_002645.3 pyruvate kinase 3 isoform 1; thyroid hormone-binding protein, cytosolic; PK, muscle type; OPA-interacting protein 3 (Homo sapiens)

* Amino acid sequence 100% similarity to Myomesin2

† Clone mapping to two Unigene clusters, Hs.435948 and Hs.524395