Table 1.
Expression difference between pools of six narcoleptic dogs and six unaffected siblings, heterozygous for the canarc-1 mutation. Similarity scores (right-most column) between the human gene and the dog orthologue was retrieved from Ensembl v39 (June 2006) and aligned with BLAST (bl2seq).
| Clone ID | Symbol | Name | PenF ratio | p-value | A | H | P | Similarity (%) |
| 2017204 | PENK | Proenkephalin | 11.0 | 0.0008 | -1.36 | -0.09 | -0.39 | 87 |
| 784179 | TAC1 | Tachykinin, precursor 1 | 8.7 | 0.0025 | -1.20 | -0.05 | -0.44 | 96 |
| 430318 | PVALB | Parvalbumin | 8.3 | 0.0044 | +0.51 | +0.91 | +0.28 | 90 |
| 824643 | CAMKK2 | Calcium/calmodulin-dependent protein kinase kinase 2, beta | 7.0 | 0.0034 | -0.49 | -0.57 | -0.44 | 92 |
| 782789 | AVPR1A | Arginine vasopressin receptor 1A | 6.3 | 0.0019 | -0.70 | -0.21 | -0.48 | 88 |
| 843426 | SAV1 | Salvador homolog 1 (Drosophila) | 6.1 | 0.0022 | +0.66 | +0.07 | +0.64 | 95 |
| 853956 | ARIH2 | Ariadne homolog 2 (Drosophila) | 5.9 | 0.0064 | -0.25 | -0.68 | -0.48 | 94 |
| 1848986 | PCYT1B | Phosphate cytidylyltransferase 1, choline, beta isoform | 5.7 | 0.0104 | -0.34 | -0.56 | -0.54 | 93 |
| 825265 | POLD3 | Polymerase (DNA-directed), delta 3, accessory subunit | 5.7 | 0.0068 | +0.45 | +0.33 | +0.61 | 90 |
| 1535596 | RDH11 | DKFZP564M1462 protein | 5.6 | 0.0050 | -0.40 | -0.30 | -0.65 | 88 |
| 838504 | SMBP | SM-11044 binding protein | 5.5 | 0.0066 | +0.66 | +0.28 | +0.42 | 95 |
| 1046495 | N/A # | 5.5 | 0.0016 | +0.02 | -0.85 | -0.44 | Not found | |
| 646753 | FLJ38736 | Hypothetical protein FLJ38736 | 5.3 | 0.0045 | -0.47 | -0.13 | -0.70 | 87 |
| 896949 | HMGCR | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 5.2 | 0.0066 | +0.44 | +0.30 | +0.56 | 92 |
| 287646 | RNF14 | Ring finger protein 14 | 5.1 | 0.0085 | +0.40 | -1.62 | -0.09 | 93 |
| 1506399 | N/A * | 5.1 | 0.0091 | -0.52 | -0.02 | -0.77 | Not found | |
| 796885 | RPL23 | Ribosomal protein L23 | 5.0 | 0.0063 | +0.74 | -0.05 | +0.59 | Not found |
| 45452 | N/A † | 5.0 | 0.0308 | -0.33 | -0.49 | -0.74 | Not found | |
| 898222 | ATPAF2 | ATP synthase mitochondrial F1 complex assembly factor 2 | 4.9 | 0.0209 | -0.38 | -0.36 | -0.68 | 88 |
| 131073 | SOCS2 | Suppressor of cytokine signaling 2 | 4.8 | 0.0044 | -0.79 | -0.16 | -0.27 | 97 |
| 308231 | MYO1B | Myosin IB | 4.8 | 0.0049 | -0.56 | -0.30 | -0.37 | 92 |
| 448708 | GAPVD1 | GTPase activating protein and VPS9 domains 1 | 4.6 | 0.0106 | +0.58 | +0.12 | +0.55 | Not found |
The eight underlined genes have been also tested with qPCR. Average differences between narcoleptics and controls larger than a log2 value corresponding to 0.7 (1.6 fold) are also underlined. N/A = not annotated in the clone database.
# Transcribed locus, moderately similar to NP_002645.3 pyruvate kinase 3 isoform 1; thyroid hormone-binding protein, cytosolic; PK, muscle type; OPA-interacting protein 3 (Homo sapiens)
* Amino acid sequence 100% similarity to Myomesin2
† Clone mapping to two Unigene clusters, Hs.435948 and Hs.524395