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. 2007 Jan;12(1):99–112. doi: 10.1016/j.devcel.2006.12.006

Figure 5.

Figure 5

Glandular Metaplasia in Mid-Ventral Skin of K14-Cre; Smof/f Mice

(A–D) Flat-mounts of postnatal mid-ventral skin from mutants. Skin stained with neutral red (A) or hematoxylin (B). Unstained skin (C and D). The skin was photographed on its dermal (A, C, and D) or epidermal (B) side. Note the numerous heterotopic glands (hg), some of which exhibit sidebranches (sb). (D) is a high-magnification view of the area indicated in (C).

(E–I) Sections from postnatal mid-ventral skin from mutants stained with Ladewig's trichrome (E, F, H, and I) or hematoxylin (G). (F) An hg that emerged from a hair follicle underneath a sebaceous gland (sg). (G) An hg with a sb. (H and I) Single hg that developed from the interfollicular epidermis (IFE).

(J) Histochemistry of mid-ventral skin from a K14-Cre; Smof/f; R26R mutant showing β-galactosidase activity in the follicular epithelum (fe), IFE, and hg. Scale bars: 50 μm (E, F, G, and I) and 100 μm (H and J).