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. 2007 Feb 7;5(2):151–156. doi: 10.1016/j.cmet.2007.01.008

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© 2007 ELL & Excerpta Medica.

This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/3.0/).

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The Effect of Exercise on AMPK in Young and Old Rats

(A) AMPK-α₂ activity in the EDL muscle of exercising or sedentary young and old rats. AMPK-α₂ activity was increased by 110% in the young exercising rats compared to the young sedentary rats. In contrast, there was no difference between the old exercising rats and old sedentary rats. (n = 8 in each group.) ^∗p = 0.01.

(B) p-ACC (Ser79) in the EDL muscle of exercising or sedentary young and old rats. Exercise resulted in a 127% increase in p-ACC (Ser79) in the young rats. In contrast, there was no effect of exercise on p-ACC (Ser79) in the old rats. (n = 4 in each group.) ^∗p < 0.05.

(C) p-AMPK (Thr172) in the EDL muscle of exercising or sedentary young and old rats. Exercise resulted in a 55% increase in p-AMPK (Thr172) in the young rats. In contrast, there was no effect of exercise on p-AMPK (Thr172) in the old rats. (n = 4 in each group.) ^∗p < 0.05.