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. 2000 Oct 24;97(23):12891–12895. doi: 10.1073/pnas.200355397

Figure 3.

Figure 3

Multiple sequence alignment of the PDE11A1, PDE11A2, and PDE11A3 GAF domains to GAF domains of other PDEs. The GAF domain boundaries were determined by the Simple Modular Architecture Tool (smart). For clarity of viewing, 35–95 nonhomologous amino acid residues from the N-terminal and C-terminal ends of the sequences delineated by smart have been omitted. Numbers in parentheses at the end of each sequence indicate the number of amino acids omitted. Stars mark the conserved sequence motif present in most GAF domains. PDE2, HSPDE2A (GenBank accession no. U67733); PDE5, HSPDE5A (AJ004865); PDE6, HSPDE6A, alpha, (NM-000440); PDE10, HSPDE10A (NM-006661); PDE11A1, HSPDE11A1 (AJ251509); PDE11A2, HSPDE11A2 (AF281865); PDE11A3, HSPDE11A3 (AJ278682).